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New Gene/Protein Targets for Antibiotics

User photo not available By Bob Nidever in Latest Additions
Published: Monday, 07 July 08 - 11:03 PM (GMT)
Investigators at UCLA have identified a high throughput screening method that allows the rapid and facile determination of bacterial genes that can be targeted by small molecule inhibitors in order to increase antibiotic potency.

Researchers at UCLA have identified a high-throughput screening method that can simultaneously identify a large number of genes that when inactive, can increase the susceptibility of bacteria to antibiotics. Small molecules could then be designed to act as inhibitors that would render the desired gene(s) inactive. Therefore, these inhibitors would act as co-antibiotics (pharmaceutical agents that enhance antibiotic activity) and allow appropriate antibiotic treatments to work effectively. MORE [2008-014]
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