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Protein Nanogels for Long-term Protein Delivery into Cells

		By Bob Nidever in Latest Additions Published: Wednesday, 25 February 09 - 09:47 PM (GMT)

UCLA scientists have developed a system of nanogels that may greatly improve protein delivery efficiency and long-term effect in protein therapy. Experiments have demonstrated that nanogels are safe, efficient in protein delivery, stable and active inside cells. Therefore, these nanogels have great potential applications in protein therapy.

Researchers at UCLA have developed a nanogel system that delivers proteins into cells with high efficiency and enhances long-term effect of proteins inside cells. Nanogels have core-shell structures that protect protein cores from chemical, mechanical, and thermal stress but allow substrates to enter the nanogels. They are very small and can be easily transmitted through cell membranes. These nanogels also have low cytotoxicity and good stability inside cells. When administrated in vivo, these nanogels are distributed in various tissues and do not accumulate in any particular organ. MORE [2009-082]
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